Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland.

BMC medical genomics - 9 Mar 2017

Kluska Anna, Balabas Aneta, Piatkowska Magdalena, Czarny Katarzyna, Paczkowska Katarzyna, Nowakowska Dorota, Mikula Michal, Ostrowski Jerzy

Abstract excerpt

BACKGROUND: The PALB2 gene encodes a protein that plays a crucial role in maintaining genomic integrity. Germline inactivating mutations in PALB2 are associated with an increased risk of breast and ovarian cancer. The prevalence and spectrum of recurrent PALB2 germline mutations in breast and ovarian cancer patients from Poland is not clearly defined. METHODS: PALB2 exons were amplified from 460 BRCA1/2-mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group N Protein

Share to Germ-Line Mutation

Share to Nuclear Proteins

Share to Ovarian Neoplasms

Share to Poland

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28279176
DOI: 10.1186/s12920-017-0251-8
PMCID: PMC5345197

Genes

PALB2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland.PMID 28279176Read ↗

A novel germline PALB2 deletion in Polish breast and ovarian cancer patients.Semantic proximity Read ↗

Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.Semantic proximity Read ↗

Frequency and molecular characteristics of PALB2-associated cancers in Russian patients.Semantic proximity Read ↗

Recurrent mutations of BRCA1, BRCA2 and PALB2 in the population of breast and ovarian cancer patients in Southern PolandSemantic proximity Read ↗

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.Semantic proximity Read ↗

Targeted massively parallel sequencing characterises the mutation spectrum of PALB2 in breast and ovarian cancer cases from Poland and Ukraine.Semantic proximity Read ↗

PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.Semantic proximity Read ↗

PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.