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Generation of germ cells from pluripotent stem cells in mammals

10 Dec 2017

Abstract excerpt

BACKGROUND: The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction have been established in the mouse. Many attempts are reported to enhance our understanding of PGC development in other mammals, including human. METHODS: Here,...

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PMID: 29692667
DOI: 10.1002/rmb2.12077

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