Article
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.
The Journal of biological chemistry - 9 Nov 2012
Della-Maria Julie, Hegde Muralidhar L, McNeill Daniel R, Matsumoto Yoshihiro, Tsai Miaw-Sheue, Ellenberger Tom, Wilson David M, Mitra Sankar, Tomkinson Alan E
Abstract excerpt
XRCC1 plays a key role in the repair of DNA base damage and single-strand breaks. Although it has no known enzymatic activity, XRCC1 interacts with multiple DNA repair proteins and is a subunit of distinct DNA repair protein complexes. Here we used the yeast two-hybrid genetic assay to identify mutant versions of XRCC1 that are selectively defective in interacting with a single protein partner. One XRCC1 mutant,...
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