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Article

DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress.

Molecular and cellular biology - 1 Sept 2009

Breslin Claire, Caldecott Keith W

Abstract excerpt

Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential for embryonic viability and that interacts with multiple DNA repair proteins. However, the relative importance of the interactions mediated by XRCC1 during...

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Source

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Identifiers

PMID: 19546231
DOI: 10.1128/MCB.00677-09
PMCID: PMC2725712

Genes

XRCC1
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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