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Article

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

Scientific reports - 9 Mar 2017

Kotani Yuri, Morito Daisuke, Sakata Kenshiro, Ainuki Shiori, Sugihara Munechika, Hatta Tomohisa, Iemura Shun-Ichiro, Takashima Seiji, Natsume Tohru, Nagata Kazuhiro

Abstract excerpt

The deubiquitylating enzyme USP15 plays significant roles in multiple cellular pathways including TGF-β signaling, RNA splicing, and innate immunity. Evolutionarily conserved skipping of exon 7 occurs during transcription of the mRNAs encoding USP15 and its paralogue USP4, yielding two major isoforms for each gene. Exon 7 of USP15 encodes a serine-rich stretch of 29 amino acid residues located in the inter-region...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28276505
DOI: 10.1038/srep44293
PMCID: PMC5343593

Genes

USP15
USP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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