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Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

26 Oct 2015

Abstract excerpt

BACKGROUND: USP4, USP15 and USP11 are paralogous deubiquitinating enzymes as evidenced by structural organization and sequence similarity. Based on known interactions and substrates it would appear that they have partially redundant roles in pathways vital to cell proliferation, development and innate immunity, and elevated expression of all three has been reported in various human malignancies. The nature and...

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PMID: 26503449
DOI: 10.1186/s12862-015-0511-1

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