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Epigenetic Changes in Prostate Cancer: Implication for Diagnosis and Treatment

18 Jan 2005

Abstract excerpt

Prostate cancer is the most common noncutaneous malignancy and the second leading cause of cancer death among men in the United States. DNA methylation and histone modifications are important epigenetic mechanisms of gene regulation and play essential roles both independently and cooperatively in tumor initiation and progression. Aberrant epigenetic events such as DNA hypo- and hypermethylation and altered...

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PMID: 15657340
DOI: 10.1093/jnci/dji010

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