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Article

Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of beta-catenin.

Oncology reports - 1 Nov 2004

Imai Mitsuho, Nakamura Tsutomu, Akiyama Tetsu, Horii Akira

Abstract excerpt

Abnormal nuclear accumulation of beta-catenin (CTNNB1) plays one of the key roles in the upregulation of the Wnt signalling pathway that can cause acceleration of cell proliferation. ICAT, inhibitor of beta-catenin and TCF4/beta-catenin-interacting protein, was isolated and mapped to 1p36, a frequent target for LOH in many human cancers. We have previously observed that a number of tumors showing abnormal...

Read the complete abstract on PubMed

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Share to Adaptor Proteins, Signal Transducing
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 1

Share to Cytoskeletal Proteins

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Share to Loss of Heterozygosity

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 15492799

Genes

CTNNB1
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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