Article
APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL.
Leukemia - 1 Oct 2017
Li Z, Abraham B J, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan S H, Sanda T, Weintraub A S, Li B, Shen S, Zhang J, Mansour M R, Young R A, Look A T
Abstract excerpt
Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovered within noncoding genomic sequences. Thus, a current challenge is to gain precise understanding of how these unique...
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