Article
Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation.
Neuropharmacology - 15 May 2017
Clark Stewart D, Kenakin Terrence P, Gertz Steven, Hassler Carla, Gay Elaine A, Langston Tiffany L, Reinscheid Rainer K, Runyon Scott P
Abstract excerpt
The neuropeptide S system has been implicated in a number of centrally mediated behaviors including memory consolidation, anxiolysis, and increased locomotor activity. Characterization of these behaviors has been primarily accomplished using the endogenous 20AA peptide (NPS) that demonstrates relatively equal potency for the calcium mobilization and cAMP second messenger pathways at human and rodent NPS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.