A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Abstract excerpt

Human tauopathies including Alzheimer's disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is associated with human tauopathy. However, it is not known how tau fragmentation affects critical molecular processes in cells...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Endoplasmic Reticulum Stress and Disease
• Share to Mitochondrial Function and Pathology