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Article

Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2017

Chiyoda Tatsuyuki, Hart Peter C, Eckert Mark A, McGregor Stephanie M, Lastra Ricardo R, Hamamoto Ryuji, Nakamura Yusuke, Yamada S Diane, Olopade Olufunmilayo I, Lengyel Ernst, Romero Iris L

Abstract excerpt

Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of developing epithelial ovarian cancer. However, beyond the role of BRCA1 in DNA repair, little is known about other mechanisms by which BRCA1 impairment promotes carcinogenesis. Given that altered metabolism is now recognized as important in the initiation and progression of cancer, we asked whether the loss of...

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Source

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Identifiers

PMID: 28264838
DOI: 10.1158/1940-6207.CAPR-16-0281
PMCID: PMC5425093

Genes

BRCA1
MYC
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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