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Article

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.

Investigative ophthalmology & visual science - 1 Mar 2017

Stanton James B, Marmorstein Alan D, Zhang Youwen, Marmorstein Lihua Y

Abstract excerpt

Purpose: EFEMP1 (fibulin-3) is mutated in Malattia Leventinese/Doyne's honeycomb retinal dystrophy (ML/DHRD), an inherited macular dystrophy similar to AMD. Both ML/DHRD and AMD are characterized by the presence of sub-RPE deposits. Efemp1 knockout mice do not develop sub-RPE deposits. This study was to test whether sub-RPE deposits can be induced in Efemp1 knockout mice by experimentally applied stress...

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Source

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Identifiers

PMID: 28264101
DOI: 10.1167/iovs.16-20955
PMCID: PMC5361459

Genes

RPE
EFEMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.PMID 28264101Read ↗

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