Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.

doi:10.1016/j.celrep.2020.108286

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Article

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.

Cell reports - 20 Oct 2020

Balakrishnan Ilango, Danis Etienne, Pierce Angela, Madhavan Krishna, Wang Dong, Dahl Nathan, Sanford Bridget, Birks Diane K, Davidson Nate, Metselaar Dennis S, Meel Michaël Hananja, Lemma Rakeb, Donson Andrew, Vijmasi Trinka, Katagi Hiroaki, Sola Ismail, Fosmire Susan, Alimova Irina, Steiner Jenna, Gilani Ahmed, Hulleman Esther, Serkova Natalie J, Hashizume Rintaro, Hawkins Cynthia, Carcaboso Angel M, Gupta Nalin, Monje Michelle, Jabado Nada, Jones Kenneth, Foreman Nicholas, Green Adam, Vibhakar Rajeev, Venkataraman Sujatha

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tumor. Using a combined RNAi and chemical screen targeting epigenomic regulators, we identify the polycomb repressive complex 1 (PRC1) component BMI1 as a critical factor for...

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PMID: 33086074
DOI: 10.1016/j.celrep.2020.108286
PMCID: PMC7574900

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