Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population.

doi:10.1093/jjco/hyw178

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Article

Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population.

Japanese journal of clinical oncology - 9 Feb 2017

Chika Noriyasu, Eguchi Hidetaka, Kumamoto Kensuke, Suzuki Okihide, Ishibashi Keiichiro, Tachikawa Tetsuhiko, Akagi Kiwamu, Tamaru Jun-Ichi, Okazaki Yasushi, Ishida Hideyuki

Abstract excerpt

OBJECTIVE: We investigated the prevalence of Lynch syndrome and Lynch-like syndrome among Japanese colorectal cancer patients, as there have been no credible data from Japan. METHODS: Immunohistochemical analyses for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) were carried out in surgically resected, formalin-fixed paraffin-embedded specimens obtained from 1,234 newly diagnosed colorectal cancer patients...

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