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Article

[Screening for Lynch syndrome in colorectal cancer].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Jun 2014

Liu Xiaohong, Cao Yongcheng, Wang Cuicui, Cao Ruixue, Chen Xin, Ding Jiyuan, Geng Ming

Abstract excerpt

OBJECTIVE: To evaluate the application of mismatch repair (MMR) genes proteins expression to screen for Lynch syndrome in colorectal cancer patients. METHODS: One hundred consecutive colorectal cancers cases collected from 2012 to 2013 were tested immunohistochemically for the protein expression of MLH1, MSH2, MSH6 and PMS2, and also by the ARMS method for the mutation status of BRAF genes in those cases lacking...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Immunohistochemistry

Share to Mutation

Share to MutL Protein Homolog 1

Share to Nuclear Proteins

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 25208990

Genes

MLH1
BRAF
MSH2
PMS2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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