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Article

Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.

The Journal of biological chemistry - 28 Apr 2017

Maruoka Masahiro, Kedashiro Shin, Ueda Yuki, Mizutani Kiyohito, Takai Yoshimi

Abstract excerpt

Cell-surface cytokine receptors are regulated by their cis-interacting stimulatory and inhibitory co-receptors. We previously showed that the Ig-like cell-adhesion molecule nectin-4 cis-interacts with the prolactin receptor through the extracellular region and stimulates prolactin-induced prolactin receptor activation and signaling, resulting in alveolar development in the mouse mammary gland. However, it remains...

Read the complete abstract on PubMed

Topics

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Share to Cell Adhesion Molecules
Share to Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Mammary Glands, Animal

Share to Prolactin

Share to Receptors, Prolactin

Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling 1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28258213
DOI: 10.1074/jbc.M116.769091
PMCID: PMC5409460

Genes

SOCS1
JAK2
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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