Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

Abstract excerpt

Abstract Semaphorin-4A (Sema4A) has been implicated in the co-stimulation of T cells and drives Th1 immune responses by binding to the receptor T-cell immunoglobulin and mucin domain protein 2 (Tim-2) in mice. Here we show that human, but not murine, Sema4A is preferentially expressed on antigen-presenting cells, and co-stimulates CD4+T-cell proliferation and drives Th2 responses. By employing two independent...

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