Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.

Brain research. Molecular brain research - 15 Nov 2002

Bartoe Joseph L, Nathanson Neil M

Abstract excerpt

The neurokine leukemia inhibitory factor (LIF) initiates signaling through heterodimerization of the low affinity LIF receptor (LIFR) and gp130. Tyrosine 759 of gp130 is required for the negative regulation of LIF-mediated signaling by both the protein tyrosine phosphatase SHP-2 and the suppresso...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline O-Acetyltransferase
Share to Cytokine Receptor gp130
Share to Growth Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia Inhibitory Factor

Share to Lymphokines

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Suppressor of Cytokine Signaling 3 Protein

Share to Suppressor of Cytokine Signaling Proteins

Source

Identifiers

PMID: 12425940
DOI: 10.1016/s0169-328x(02)00452-7

Genes

LIF
VIP
STAT1
CNTF
LIFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12425940-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.PMID 12425940Read ↗

SOCS3 negatively regulates LIF signaling in neural precursor cells.Semantic proximity Read ↗

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.Semantic proximity Read ↗

Multiple promoter elements required for leukemia inhibitory factor-stimulated M2 muscarinic acetylcholine receptor promoter activity.Semantic proximity Read ↗

Cytokine signaling in the brain: Putting a SOCS in it?Semantic proximity Read ↗

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory diseaseSemantic proximity Read ↗

The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling.Semantic proximity Read ↗

Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cellsSemantic proximity Read ↗

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog MedulloblastomaSemantic proximity Read ↗

STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells.Semantic proximity Read ↗

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.Semantic proximity Read ↗

Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1.Semantic proximity Read ↗

Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.