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Article

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii

1 Mar 2017

Abstract excerpt

Toxoplasma gondii , like all apicomplexan parasites, uses Ca 2+ signaling pathways to activate gliding motility to power tissue dissemination and host cell invasion and egress. A group of "plant-like" Ca 2+ -dependent protein kinases (CDPKs) transduces cytosolic Ca 2+ flux into enzymatic activity, but how they function is poorly understood. To investigate how Ca 2+ signaling activates egress through CDPKs, we...

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PMID: 28258212
DOI: 10.1074/jbc.m117.775114

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