Article

Functional Analysis of the Expanded Phosphodiesterase Gene Family in <i>Toxoplasma gondii</i> Tachyzoites

2021-09-22

Abstract excerpt

Toxoplasma motility is both activated and suppressed by 3’-5’ cyclic nucleotide signaling. Cyclic GMP (cGMP) signaling through TgPKG activates motility, whereas cyclic AMP (cAMP) signaling through TgPKAc1 inhibits motility. Despite their importance, it remains unclear how cGMP and cAMP levels are maintained in Toxoplasma . Phosphodiesterases (PDEs) are known to inactivate cyclic nucleotides and are highly expande...

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Literature Corpus work: 5875c020-6602-598b-b73a-27f09182be43
DOI: 10.1101/2021.09.21.461320

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