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TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis

19 Mar 2018

Abstract excerpt

ABSTRACT In the protozoan parasite Toxoplasma gondii , protein kinases have been shown to play key roles in regulating parasite motility, invasion, replication, egress, and survival within the host. The tyrosine kinase-like (TKL) family of proteins are an unexplored set of kinases in Toxoplasma . Of the eight annotated TKLs in the Toxoplasma genome, a recent genome-wide loss-of-function screen showed that six are...

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PMID: 29559568
DOI: 10.1128/mbio.00301-18

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