Article
Bimodal expression of yeast GAL genes is controlled by a long non-coding RNA and a bifunctional galactokinase.
Biochemical and biophysical research communications - 22 Apr 2017
Zacharioudakis Ioannis, Tzamarias Dimitris
Abstract excerpt
Bimodality in gene expression can generate phenotypic heterogeneity facilitating fitness and growth of isogenic cell populations in suboptimal environments. We investigated the mechanism by which, in conditions of limiting galactose, yeast cell populations activate GAL genes in a bimodal fashion with a cell fraction expressing GAL genes (ON), while the rest subpopulation is kept at the non-expressing (OFF) state....
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