Article
Mismatched HLA-DRB3 Can Induce a Potent Immune Response After HLA 10/10 Matched Stem Cell Transplantation.
Transplantation - 1 Dec 2017
van Balen Peter, van Luxemburg-Heijs Simone A P, van de Meent Marian, van Bergen Cornelis A M, Halkes Constantijn J M, Jedema Inge, Falkenburg J H Frederik
Abstract excerpt
BACKGROUND: Donors for allogeneic stem cell transplantation are preferentially matched with patients for HLA-A, -B, -C, and -DRB1. Mismatches between donor and patient in these alleles are associated with an increased risk of graft-versus-host disease (GVHD). In contrast, HLA-DRB3, 4 and 5, HLA-DQ and HLA-DP are usually assumed to be low expression loci with limited relevance, although mismatches in HLA-DQ and...
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