Article
Higher risk for chronic graft-versus-host disease (GvHD) in HLA-G mismatched transplants following allogeneic hematopoietic stem cell transplantation: A retrospective study.
HLA - 1 Oct 2022
Neuchel Christine, Gowdavally Sowmya, Tsamadou Chrysanthi, Platzbecker Uwe, Sala Elisa, Wagner-Drouet Eva, Valerius Thomas, Kröger Nicolaus, Wulf Gerald, Einsele Hermann, Thurner Lorenz, Schaefer-Eckart Kerstin, Freitag Sebastian, Casper Jochen, Dürholt Mareike, Kaufmann Martin, Hertenstein Bernd, Klein Stefan, Ringhoffer Mark, Frank Sandra, Amann Elisa Maria, Rode Immanuel, Schrezenmeier Hubert, Mytilineos Joannis, Fürst Daniel
Abstract excerpt
INTRODUCTION: Graft-versus-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is highly influenced by the degree of HLA matching between recipient and donor. The HLA-class Ib molecule HLA-G has been shown to promote tolerogenicity through its interaction with inhibitory receptors found on several immunocompetent cells. We hypothesized that in an...
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