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Article

Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396.

Journal of virology - 15 Sept 2016

Murgatroyd Christopher, Pirrie Lisa, Tran Fanny, Smith Terry K, Westwood Nicholas J, Adamson Catherine S

Abstract excerpt

UNLABELLED: HIV-1 maturation inhibitors are a novel class of antiretroviral compounds that consist of two structurally distinct chemical classes: betulinic acid derivatives and the pyridone-based compound PF-46396. It is currently believed that both classes act by similar modes of action to generate aberrant noninfectious particles via inhibition of CA-SP1 cleavage during Gag proteolytic processing. In this...

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Share to Anti-HIV Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Jurkat Cells

Share to Molecular Structure

Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 27384665
DOI: 10.1128/JVI.01075-16
PMCID: PMC5008107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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