Article
Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.
Scientific reports - 2 Mar 2017
Fujikawa Yusuke, Yoshida Hideyuki, Inoue Tadashi, Ohbayashi Tetsuya, Noda Kazuo, von Melchner Harald, Iwasaka Toshiji, Shiojima Ichiro, Akama Tomoya O, Nakamura Tomoyuki
Abstract excerpt
Microfibrils are exracellular matrix components necessary for elastic fiber assembly and for suspending lenses. We previously reported that latent TGF-β binding protein 2 (LTBP-2), a microfibril-associated protein, is required for forming stable microfibril bundles in ciliary zonules. However, it was not understood why Ltbp2 null mice only showed an eye-specific phenotype, whereas LTBP-2 is abundantly expressed...
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