Article
Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression.
PLoS genetics - 1 Jan 2013
Paris Mathilde, Kaplan Tommy, Li Xiao Yong, Villalta Jacqueline E, Lott Susan E, Eisen Michael B
Abstract excerpt
To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in blastoderm embryos of four species, which sample much of the diversity in the 40 million-year old genus Drosophila: D. melanogaster, D. yakuba, D. pseudoobscura and D. virilis. We compared gene expression, measured by mRNA-seq, to...
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