Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.

doi:10.1053/j.gastro.2017.02.018

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Article

Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.

Gastroenterology - 1 Jun 2017

Weiler Sofia M E, Pinna Federico, Wolf Thomas, Lutz Teresa, Geldiyev Aman, Sticht Carsten, Knaub Maria, Thomann Stefan, Bissinger Michaela, Wan Shan, Rössler Stephanie, Becker Diana, Gretz Norbert, Lang Hauke, Bergmann Frank, Ustiyan Vladimir, Kalin Tatiana V, Singer Stephan, Lee Ju-Seog, Marquardt Jens U, Schirmacher Peter, Kalinichenko Vladimir V, Breuhahn Kai

Abstract excerpt

BACKGROUND & AIMS: Many different types of cancer cells have chromosome instability. The hippo pathway leads to phosphorylation of the transcriptional activator yes-associated protein 1 (YAP1, YAP), which regulates proliferation and has been associated with the development of liver cancer. We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarcinogenesis in humans and mice....

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Identifiers

PMID: 28249813
DOI: 10.1053/j.gastro.2017.02.018

Genes

FOXM1
TEAD4
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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