Article
AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer.
Cellular and molecular life sciences : CMLS - 19 Dec 2022
Schneeweis Christian, Diersch Sandra, Hassan Zonera, Krauß Lukas, Schneider Carolin, Lucarelli Daniele, Falcomatà Chiara, Steiger Katja, Öllinger Rupert, Krämer Oliver H, Arlt Alexander, Grade Marian, Schmidt-Supprian Marc, Hessmann Elisabeth, Wirth Matthias, Rad Roland, Reichert Maximilian, Saur Dieter, Schneider Günter
Abstract excerpt
Targeting KRAS downstream signaling remains an important therapeutic approach in pancreatic cancer. We used primary pancreatic ductal epithelial cells and mouse models allowing the conditional expression of oncogenic KrasG12D, to investigate KRAS signaling integrators. We observed that the AP1 family member FRA1 is tightly linked to the KRAS signal and expressed in pre-malignant lesions and the basal-like subtype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.