Article
Serum resistin is causally related to mortality risk in patients with type 2 diabetes: preliminary evidences from genetic data.
Scientific reports - 3 Mar 2017
Fontana Andrea, Ortega Moreno Lorena, Lamacchia Olga, De Bonis Concetta, Salvemini Lucia, De Cosmo Salvatore, Cignarelli Mauro, Copetti Massimiliano, Trischitta Vincenzo, Menzaghi Claudia
Abstract excerpt
Resistin has been firmly associated with all-cause mortality. We investigated, whether, in patients with type 2 diabetes (T2D), this association is sustained by a cause-effect relationship. A genotype risk score (GRS), created by summing the number of resistin increasing alleles of two genome-wide association studies (GWAS)-derived single nucleotide polymorphisms (SNPs), serum resistin measurements and all-cause...
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