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Article

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

Development (Cambridge, England) - 1 Mar 2017

Zhu Jun-Yi, Heidersbach Amy, Kathiriya Irfan S, Garay Bayardo I, Ivey Kathryn N, Srivastava Deepak, Han Zhe, King Isabelle N

Abstract excerpt

miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle and embryonic heart development, which have been partly attributed to miR-1 directly targeting Delta to decrease Notch signaling. Here, we show that overexpression of miR-1 in the fly wing can paradoxically increase Notch activity independently of its...

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Identifiers

PMID: 28246214
DOI: 10.1242/dev.140368
PMCID: PMC5374346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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