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Article

Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice.

Gastroenterology - 1 Jun 2017

Hong Chun-Pyo, Park Areum, Yang Bo-Gie, Yun Chang Ho, Kwak Min-Jung, Lee Gil-Woo, Kim Jung-Hwan, Jang Min Seong, Lee Eun-Jung, Jeun Eun-Ji, You Gihoon, Kim Kwang Soon, Choi Youngwoo, Park Ji-Hwan, Hwang Daehee, Im Sin-Hyeog, Kim Jihyun F, Kim Yoon-Keun, Seoh Ju-Young, Surh Charles D, Kim You-Me, Jang Myoung Ho

Abstract excerpt

BACKGROUND & AIMS: Obesity and metabolic syndrome have been associated with alterations to the intestinal microbiota. However, few studies examined the effects of obesity on the intestinal immune system. We investigated changes in subsets of intestinal CD4+ T-helper (TH) cells with obesity and the effects of gut-tropic TH17 cells in mice on a high-fat diet (HFD). METHODS: We isolated immune cells from small...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28246016
DOI: 10.1053/j.gastro.2017.02.016

Genes

RAG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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