Article
Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.
Diabetes - 1 Feb 2012
van der Weerd Kim, Dik Willem A, Schrijver Benjamin, Schweitzer Dave H, Langerak Anton W, Drexhage Hemmo A, Kiewiet Rosalie M, van Aken Maarten O, van Huisstede Astrid, van Dongen Jacques J M, van der Lelij Aart-Jan, Staal Frank J T, van Hagen P Martin
Abstract excerpt
Obesity is associated with local T-cell abnormalities in adipose tissue. Systemic obesity-related abnormalities in the peripheral blood T-cell compartment are not well defined. In this study, we investigated the peripheral blood T-cell compartment of morbidly obese and lean subjects. We determined all major T-cell subpopulations via six-color flow cytometry, including CD8+ and CD4+ T cells, CD4+ T-helper (Th)...
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