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T cell–mediated regulation of the microbiota protects against obesity

25 Jul 2019

Abstract excerpt

T cells help keep you lean The gut microbiota is a critical factor regulating mammalian metabolism. The host immune system, in turn, can shape the microbiome, in part via immunoglobulin A (IgA) antibodies. Petersen et al. report that mice defective in T follicular helper cell development and gut IgA production show hallmarks of metabolic syndrome with age (see the Perspective by Wang and Hooper). These mice gain...

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PMID: 31346040
DOI: 10.1126/science.aat9351

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