Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Carolan Eirin, Tobin Laura M, Mangan Bozgana A, Corrigan Michelle, Gaoatswe Gadinthsware, Byrne Greg, Geoghegan Justin, Cody Declan, O'Connell Jean, Winter Desmond C, Doherty Derek G, Lynch Lydia, O'Shea Donal, Hogan Andrew E

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through the rapid production of cytokines. In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion is associated with diabetic status. Circulating MAIT cells more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated in insulin resistance....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Interleukin-17

Share to Lymphocyte Count

Share to Mucous Membrane

Share to Obesity

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 25980010
DOI: 10.4049/jimmunol.1402945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity.PMID 25980010Read ↗

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.Semantic proximity Read ↗

Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?Semantic proximity Read ↗

iNKT and MAIT Cell Alterations in DiabetesSemantic proximity Read ↗

T cell dysregulation and remodeling in pediatric obesity and weight lossSemantic proximity Read ↗

Tissue-Specific Phenotype and Activation of iNKT Cells in Morbidly Obese Subjects: Interaction with Adipocytes and Effect of Bariatric Surgery.Semantic proximity Read ↗

Visceral adipose tissue Tregs and the cells that nurture themSemantic proximity Read ↗

A Unique Population: Adipose-Resident Regulatory T CellsSemantic proximity Read ↗

The Immune Landscape of Visceral Adipose Tissue During Obesity and AgingSemantic proximity Read ↗

Rapid adipose tissue expansion triggers proliferation of memory adipose tissue T cells and accumulation of novel T helper 2 (Th2) regulatory cellsSemantic proximity Read ↗

Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic healthSemantic proximity Read ↗

Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.Semantic proximity Read ↗

Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.