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Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

7 Dec 2012

Abstract excerpt

SIGNIFICANCE: Mitochondria are fundamental to the life and proper functioning of cells. These organelles play a key role in energy production, in maintaining homeostatic levels of second messengers (e.g., reactive oxygen species and calcium), and in the coordination of apoptotic cell death. The role of mitochondria in aging and in pathophysiological processes is constantly being unraveled, and their involvement...

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PMID: 23216311
DOI: 10.1089/ars.2012.5039

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