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Article

Molecular biomarkers predictive of sertraline treatment response in young children with fragile X syndrome.

Brain & development - 1 Jun 2017

AlOlaby Reem Rafik, Sweha Stefan R, Silva Marisol, Durbin-Johnson Blythe, Yrigollen Carolyn M, Pretto Dalyir, Hagerman Randi J, Tassone Flora

Abstract excerpt

OBJECTIVES: Several neurotransmitters involved in brain development are altered in fragile X syndrome (FXS), the most common monogenic cause of autism spectrum disorder (ASD). Serotonin plays a vital role in synaptogenesis and postnatal brain development. Deficits in serotonin synthesis and abnormal neurogenesis were shown in young children with autism, suggesting that treating within the first years of life with...

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Share to Autism Spectrum Disorder
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Double-Blind Method

Share to Fragile X Syndrome

Share to Matrix Metalloproteinase 9

Share to Monoamine Oxidase

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28242040
DOI: 10.1016/j.braindev.2017.01.012
PMCID: PMC5420478

Genes

BDNF
MAOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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