Article
SLC6A4 markers modulate platelet 5-HT level and specific behaviors of autism: a study from an Indian population.
Progress in neuro-psychopharmacology & biological psychiatry - 2 Jan 2015
Jaiswal Preeti, Guhathakurta Subhrangshu, Singh Asem Surindro, Verma Deepak, Pandey Mritunjay, Varghese Merina, Sinha Swagata, Ghosh Saurabh, Mohanakumar Kochupurackal P, Rajamma Usha
Abstract excerpt
Presence of platelet hyperserotonemia and effective amelioration of behavioral dysfunctions by selective serotonin reuptake inhibitors (SSRI) in autism spectrum disorders (ASD) indicate that irregularities in serotonin (5-HT) reuptake and its homeostasis could be the basis of behavioral impairments in ASD patients. SLC6A4, the gene encoding serotonin transporter (SERT) is considered as a potential susceptibility...
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