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Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular Dysfunction

2026-04-15

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Obstructive Sleep Apnea (OSA) is a pervasive cardiovascular risk factor linked to accelerated aging and systemic inflammation. Intermittent hypoxia (IH)—a hallmark of OSA—induces cardiovascular decline, yet the underlying tissue-specific and systemic epigenetic mechanisms and the role of cellular senescence in the pathophysiology of OSA and associated cardio...

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Literature Corpus work: 246095f8-224d-5106-b325-7da46716450c
DOI: 10.21203/rs.3.rs-9371471/v1

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