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Article

PDGFRα/PDGFRβ signaling balance modulates progenitor cell differentiation into white and beige adipocytes

21 Nov 2017

Abstract excerpt

The relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose tissue function have remained unclear. Here, by defining the developmental timing of PDGFRα and PDGFRβ expression in mouse subcutaneous and visceral adipose depots, we uncover depot...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 29158445
DOI: 10.1242/dev.155861

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