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Article

Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines.

Endocrine-related cancer - 1 May 2017

Woodward Eleanor L, Biloglav Andrea, Ravi Naveen, Yang Minjun, Ekblad Lars, Wennerberg Johan, Paulsson Kajsa

Abstract excerpt

Anaplastic thyroid cancer (ATC) is a highly malignant disease with a very short median survival time. Few studies have addressed the underlying somatic mutations, and the genomic landscape of ATC thus remains largely unknown. In the present study, we have ascertained copy number aberrations, gene fusions, gene expression patterns, and mutations in early-passage cells from ten newly established ATC cell lines...

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Topics

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Share to Genetic Heterogeneity
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Instability

Share to High-Throughput Nucleotide Sequencing

Share to Molecular Targeted Therapy

Share to Sequence Analysis, RNA

Share to Thyroid Carcinoma, Anaplastic

Source

Identifiers

PMID: 28235956
DOI: 10.1530/ERC-16-0522

Genes

BRAF
NEGR1
NRAS
PTPRD
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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