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Article

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.

Nature communications - 24 Feb 2017

Takeda Kazuyoshi, Nakayama Masafumi, Hayakawa Yoshihiro, Kojima Yuko, Ikeda Hiroaki, Imai Naoko, Ogasawara Kouetsu, Okumura Ko, Thomas David M, Smyth Mark J

Abstract excerpt

Genetic evolution that occurs during cancer progression enables tumour heterogeneity, thereby fostering tumour adaptation, therapeutic resistance and metastatic potential. Immune responses are known to select (immunoedit) tumour cells displaying immunoevasive properties. Here we address the role of IFN-γ in mediating the immunoediting process. We observe that, in several mouse tumour models such as HA-expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 28233863
DOI: 10.1038/ncomms14607
PMCID: PMC5333095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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