Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors.

doi:10.21873/cgp.20481

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Article

Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors.

Cancer genomics & proteomics - 1 Jan 2000

Ishiguro Tomoyuki, Takeda Kazuyuki, Takayanagi Daisuke, Mura Emiko, Suzuki Risako, Tsurui Toshiaki, Iriguchi Nana, Hirasawa Yuya, Ohkuma Ryotaro, Shimokawa Masahiro, Ariizumi Hirotsugu, Kubota Yutaro, Horiike Atsushi, Izumizaki Masahiko, Wada Satoshi, Yoshimura Kiyoshi, Hoffman Robert M, Tsunoda Takuya

Abstract excerpt

BACKGROUND/AIM: The Kaplan-Meier curves for patients treated with immune checkpoint inhibitors (ICIs) display a small group of potentially-cured patients with long-term survival, creating a 'kangaroo-tail' shape of the survival curve. However, the mechanistic basis of this phenomenon and what occurs in patients whose cancer is resistant to ICIs remain unclear. The present study aimed to answer these questions....

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Identifiers

PMID: 39730175
DOI: 10.21873/cgp.20481
PMCID: PMC11696327

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