Article
Immunoediting of cancers may lead to epithelial to mesenchymal transition.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2006
Knutson Keith L, Lu Hailing, Stone Brad, Reiman Jennifer M, Behrens Marshall D, Prosperi Christine M, Gad Ekram A, Smorlesi Arianna, Disis Mary L
Abstract excerpt
Tumors evade both natural and pharmacologically induced (e.g., vaccines) immunity by a variety of mechanisms, including induction of tolerance and immunoediting. Immunoediting results in reshaping the immunogenicity of the tumor, which can be accompanied by loss of Ag expression and MHC molecules. In this study, we evaluated immunoediting in the neu-transgenic mouse model of breast cancer. A tumor cell line that...
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