Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho.

doi:10.1158/1078-0432.CCR-17-0201

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Article

Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2017

Behera Reeti, Kaur Amanpreet, Webster Marie R, Kim Suyeon, Ndoye Abibatou, Kugel Curtis H, Alicea Gretchen M, Wang Joshua, Ghosh Kanad, Cheng Phil, Lisanti Sofia, Marchbank Katie, Dang Vanessa, Levesque Mitchell, Dummer Reinhard, Xu Xiaowei, Herlyn Meenhard, Aplin Andrew E, Roesch Alexander, Caino Cecilia, Altieri Dario C, Weeraratna Ashani T

Abstract excerpt

Purpose: Aging is a poor prognostic factor for melanoma. We have shown that melanoma cells in an aged microenvironment are more resistant to targeted therapy than identical cells in a young microenvironment. This is dependent on age-related secreted factors. Klotho is an age-related protein whose serum levels decrease dramatically by age 40. Most studies on klotho in cancer have focused on the expression of...

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PMID: 28232477
DOI: 10.1158/1078-0432.CCR-17-0201
PMCID: PMC5474161

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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