Article
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Nature - 14 Apr 2016
Kaur Amanpreet, Webster Marie R, Marchbank Katie, Behera Reeti, Ndoye Abibatou, Kugel Curtis H, Dang Vanessa M, Appleton Jessica, O'Connell Michael P, Cheng Phil, Valiga Alexander A, Morissette Rachel, McDonnell Nazli B, Ferrucci Luigi, Kossenkov Andrew V, Meeth Katrina, Tang Hsin-Yao, Yin Xiangfan, Wood William H, Lehrmann Elin, Becker Kevin G, Flaherty Keith T, Frederick Dennie T, Wargo Jennifer A, Cooper Zachary A, Tetzlaff Michael T, Hudgens Courtney, Aird Katherine M, Zhang Rugang, Xu Xiaowei, Liu Qin, Bartlett Edmund, Karakousis Giorgos, Eroglu Zeynep, Lo Roger S, Chan Matthew, Menzies Alexander M, Long Georgina V, Johnson Douglas B, Sosman Jeffrey, Schilling Bastian, Schadendorf Dirk, Speicher David W, Bosenberg Marcus, Ribas Antoni, Weeraratna Ashani T
Abstract excerpt
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumour progression have been largely unexplored. Since dermal fibroblasts can have profound impacts on melanoma progression, we examined whether...
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