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Article

Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.

The Journal of biological chemistry - 1 Sept 2021

Caval Vincent, Suspène Rodolphe, Khalfi Pierre, Gaillard Julien, Caignard Grégory, Vitour Damien, Roingeard Philippe, Vartanian Jean-Pierre, Wain-Hobson Simon

Abstract excerpt

The human APOBEC3A (A3A) cytidine deaminase is a powerful DNA mutator enzyme recognized as a major source of somatic mutations in tumor cell genomes. However, there is a discrepancy between APOBEC3A mRNA levels after interferon stimulation in myeloid cells and A3A detection at the protein level. To understand this difference, we investigated the expression of two novel alternative "A3Alt" proteins encoded in...

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Identifiers

PMID: 34403699
DOI: 10.1016/j.jbc.2021.101081
PMCID: PMC8424220

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