Article
Decreased HoxD10 Expression Promotes a Proliferative and Aggressive Phenotype in Prostate Cancer.
Current molecular medicine - 1 Jan 2017
Mo R-J, Lu J-M, Wan Y-P, Hua W, Liang Y-X, Zhuo Y-J, Kuang Q-W, Liu Y-L, He H-C, Zhong W-D
Abstract excerpt
HoxD10 gene plays a critical role in cell proliferation in the process of tumor development. However, the protein expression level and the function of HoxD10 in prostate cancer remain unknown. Using tissue microarray, we demonstrate that the protein expression of HoxD10 is commonly decreased in prostate cancer tissues (n = 92) compared to adjacent benign prostate tissues (n = 77). Functionally, knockdown of...
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