Article
Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells.
Biochemical and biophysical research communications - 11 Sept 2009
Kobayashi Takashi, Nakamura Eijiro, Shimizu Yosuke, Terada Naoki, Maeno Atsushi, Kobori Go, Kamba Tomomi, Kamoto Toshiyuki, Ogawa Osamu, Inoue Takahiro
Abstract excerpt
Despite well known oncogenic function of G1-S cell-cycle progression, cyclin D2 (CCND2) is often silenced epigenetically in prostate cancers. Here we show that CCND2 has an inhibitory potential on the proliferation of androgen receptor (AR)-dependent prostate cancer LNCaP cells. Forced expression of CCND2 suppressed the proliferative ability and induced cell death in LNCaP cells in a cdk-independent manner....
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